NpgRJ_Nn_2008 1569..1577
نویسندگان
چکیده
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.
منابع مشابه
A pharmacological analysis of the adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the rainbow trout (Salmo gairdneri).
WOOD, C. M. 1975. A pharmacological analysis of the adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the rainbow trout (Salmo gairdneri). Can. J. Zool. 53: 1569-1577. The adrenergic and cholinergic mechanisms regulating branchial vascular resistance in the trout have been studied using a whole gill preparation perfused at constant flow under approximately normal...
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